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논문검색은 역시 페이퍼서치

> 대한피부과학회 > 프로그램북(구 초록집) > 67권 2호

P005 : Anti-wrinkle efficacy and safety of micro-spicule containing epidermal growth factor

P005 : Anti-wrinkle efficacy and safety of micro-spicule containing epidermal growth factor

( Jeong Min Ha ) , ( Kyuboem Han ) , ( Jong Cheon Ha ) , ( Hae Eul Lee ) , ( Young Lee ) , ( Young Joon Seo ) , ( Chang Deok Kim ) , ( Jeung Hoon Lee ) , ( Myung Im )

- 발행기관 : 대한피부과학회

- 발행년도 : 2015

- 간행물 : 프로그램북(구 초록집), 67권 2호

- 페이지 : pp.396-397 ( 총 2 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

1,000
논문제목
초록(외국어)
Background: Microneedle patch recently have been used to increase skin permeability improving drug delivery and for cosmetic purposes. However, such treatment may fail if skin penetration is insufficient reducing drug delivery or if compliance is reduced by discomfort.Objectives: : To evaluate the efficacy and the safety of microspicules containing epidermal growth factor (MS-EGF) used to treat periorbital wrinkles. Methods: Twenty health volunteers were enrolled in a randomized, controlled, split-face study. One periorbital area was treated daily with soluble MS-EGF and the other with EGF cream, for 4 weeks; all subjects underwent 8 weeks of follow-up. Efficacy was assessed using a wrinkle severity rating scale (WSRS), subjective satisfaction scores, digital skin image analysis, examination of skin replicas, and ultrasonic measurement of dermal depth and density. Results: Both the MS-EGF and EGF alone yielded positive effects on digital skin image analysis, skin replica examination, and ultrasound. However, the MS-EGF groupexhibited significant improvements in dermal depth and density, and on replica analysis, compared to theEGF-only group (P < 0.05). In addition, the MS-EGF group showed a significantly greater change in WSRS score compared to baseline than the EGF-alone group. Both treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periorbital wrinkles.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 67권 2호
  • - 발행년도 : 2015
  • - 페이지 : pp.396-397 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2016-510-000339295
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2021
  • - 수록 논문수 : 24140