글로버메뉴 바로가기 본문 바로가기 하단메뉴 바로가기

논문검색은 역시 페이퍼서치

> 대한피부과학회 > 프로그램북(구 초록집) > 67권 2호

P196 : Adiponectin ameliorate cellular premature senescence and restitute abnormal increase of antimicrobial peptide level in senescent keratinocyte

P196 : Adiponectin ameliorate cellular premature senescence and restitute abnormal increase of antimicrobial peptide level in senescent keratinocyte

( Ji Yeon Hong ) , ( Joon Seok ) , ( Tae Won Jin ) , ( Kui Young Park ) , ( Seong Joon Seo ) , ( Chang Kwun Hong )

- 발행기관 : 대한피부과학회

- 발행년도 : 2015

- 간행물 : 프로그램북(구 초록집), 67권 2호

- 페이지 : pp.481-482 ( 총 2 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

1,000
논문제목
초록(외국어)
Background: Adiponectin had been nominated as a positive factor on functional recovery for its virtue against energy metabolism related regulation especially with AMP-activated protein kinase (AMPK) and SIRT1. But there are few reports related with skin or keratinocytes. Objectives: We aim to recover the possibility of adiponectin as a promising anti-aging agent and supplement for antimicrobial barrier. Methods: Adiponectin had been treated to normal or premature senescent keratinocytes. SA モ-galactosidase stain and assay, AMPK-SIRT1-FoxOs and MAPK/NFリB signal transduction pathway were evaluated by immunoblot, SIRT1 activity assay and RT-PCR. Results: The adiponectin stimulation reduced premature senescence and restituted human モ-defensin 2 and LL-37 in aged skin. Adiponectin upregulated and recovered AMPK activity in senescent keratinocyte and up-regulated SIRT1 activity suppressed NFリB p65. Conclusion: These evidences suggest the positive possibilities of anti-aging agent and improved skin immune barrier through adiponectin stimulation related signal transduction.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 67권 2호
  • - 발행년도 : 2015
  • - 페이지 : pp.481-482 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2016-510-000331542
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2021
  • - 수록 논문수 : 24140