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> 대한소아감염학회 > Pediatric Infection and Vaccine > 3권 2호

메티실린 내성 황색 포도상 구균에서 mecA, femA 유전자의 임상적 의의

Detection of Methicillin-Resistant Staphylococcus aureus by In Vitro Enzymatic Amplification of MacA and FemA Gene

박정은 ( Jung-eun Park ) , 김택선 ( Taek-sun Kim ) , 박수성 ( Su-sung Park ) , 김은령 ( Eun-ryoung Kim ) , 김일수 ( Il-su Kim ) , 안일영 ( Il-young Ann ) , 김영진 ( Young-jin Kim ) , 짐재종 ( Jae-jong Kim ) , 강성옥 ( Sung-ok Kang ) , 박한오 ( Han-ho Park )

- 발행기관 : 대한소아감염학회

- 발행년도 : 1996

- 간행물 : Pediatric Infection and Vaccine, 3권 2호

- 페이지 : pp.133-138 ( 총 6 페이지 )


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초록(외국어)
Purpose : In the treatment of MRSA infection, rapid detection of MRSA is extremely important. The mecA gene codes the new drug resistant polypeptides called PBP2’ which mediates the clinically relevant resistance to all beta-lactam antibiotics. The identical mecA gene has been found in coagulase-negative staphylococcus with the methicillin-resistant phenotype. On the other hand, the femA gene was absent from coagulase negative staphylococcus strains with the methicillin resistant phenotype. This study is aimed at early detection and definite diagnosis of MRSA. Methods : A total of 24 MRSA strains were studied. All strains were tested for antimicrobial susceptibility and purified DNA. We amplified both mecA and femA genes by PCR in 24 strains. Results : In MRSA all the 16 strains (100%) carried femA gene and 11 strains (68.7%) carried mecA gene. In contrast, in methicillin sensitive staphylococcus all the 8 strains (100%) carried femA and only 3 strains (37.5%) were detected mecA. Conclusions : As results, there are difference in the phenotype and genotype of methi-cillin resistance by PCR of mecA and femA. Such disparities between methicillin resistance and the presence of mecA gene suggest the presence of control gene of the mecA.

논문정보
  • - 주제 : 의약학분야 > 소아과학
  • - 발행기관 : 대한소아감염학회
  • - 간행물 : Pediatric Infection and Vaccine, 3권 2호
  • - 발행년도 : 1996
  • - 페이지 : pp.133-138 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2017-510-000435430
저널정보
  • - 주제 : 의약학분야 > 소아과학
  • - 성격 : 학술지
  • - 간기 : 연3회
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 2384-1079
  • - 수록범위 : 1994–2021
  • - 수록 논문수 : 753