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논문검색은 역시 페이퍼서치

> 대한소아감염학회 > Pediatric Infection and Vaccine > 3권 2호

소아의 연령증가에 따른 볼거리 및 풍진 항체

Mumps & Rubella-specific lgG in MMR Vaccinees

전혜원 ( Heaewon Cheon ) , 신영규 ( Kangwoo Lee ) , 이강우 ( Youngkyoo Lee ) , 정지태 ( Jitae Chung ) , 독고영창 ( Youngchang Tockgo )

- 발행기관 : 대한소아감염학회

- 발행년도 : 1996

- 간행물 : Pediatric Infection and Vaccine, 3권 2호

- 페이지 : pp.175-184 ( 총 10 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

4,500
논문제목
초록(외국어)
Purpose : This study was intended to measure seropositivities and the levels of mumps-and rubella-specific IgG of MMR vaccines over 17 months of age in Korea. Materials and Methods : From June 1994 to April 1995 we obtained sera from visitors of well baby clinic and patients in Korea University Hospital, who were MMR vaccinees over 17 months of age and had no evidence of immunodeficiency. These 275 study population include 145 males and 130 females. Mumps- and rubella-specific IgG antibody levels were measured by ELISA. Cut-off values for seropositivity were 20 GU(Gamma Unit) in mumps and 0.17 in rubella. Results : 1) As age increased, seropositivities of mumps-specific IgG increased significantly, being 69.0% in 1.5~2 year, 75.0% in 3~4 year, 76.0% in 5~6 year, 90.0% in 7 year, 100% in 8 year, 96.9% in 9 year, 97.4% in 10 year, 97.4% in 11 year, and 96.6% in 12 year of age (p<0.001). 2) As age increased, the levels of mumps-specific IgG antibody(mean±standard deviation, GU) increased significantly, being 64.9±66.5 in 1.5-2 year, 117.7±126.4 in 3~4 year, 152.3±147.1 in 5~6 year, 194.3±168.2 in 7 year, 258.1±190.6 in 8 year, 193.1±130.1 in 9 year, 225.7±119.6 in 10 year, 220.7±114.3 in 11 year, and 222.3±127.1 in 12 year of age(p<0.001). There was positive correlation between age and mumps-specific antibody level (r=0.3282, p<0.001). 3) As age increased, seropositivities of rubella-specific IgG decreased significantly, being 72.4% in 1.5~2 year, 75% in 3~4 year, 72% in 5~6 year, 60% in 7 year, 44.4% in 8 year, 40.6% in 9 year, 28.2% in 10 year, 23.1% in 11 year, and 17.2% in 12 year of age(p<0.001). 4) As age increased, rubella-specific IgG decreased significantly, being 0.462±0.356 in 1.5~2year, 0.438±0.306 in 3~4 year, 0.287±0.179 in 5~6 year, 0.204±0.139 in 7 year, 0.189±0.153 in 8 year, 0.124±0.121 in 9 year, 0.093±0.114 in 10 year, 0.104±0.135 in 11 year, and 0.080±0.001 in 12 year of age(p<0.001). There was negative correlation between age and rubella-specific IgG titer (r=-0.551, p<0.001). Conclusions : Eventhough seropositivities and the level of mumps-specific IgG increased as age increased, they are not enough to prevent mumps infection in 1.5 to 6 years of age. Seropositivities and the level of rubella-specific IgG decreased as age increased. Appropriate change in vaccine schedule may be needed to decrease the risks of mumps and rubella infection.

논문정보
  • - 주제 : 의약학분야 > 소아과학
  • - 발행기관 : 대한소아감염학회
  • - 간행물 : Pediatric Infection and Vaccine, 3권 2호
  • - 발행년도 : 1996
  • - 페이지 : pp.175-184 ( 총 10 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2017-510-000435490
저널정보
  • - 주제 : 의약학분야 > 소아과학
  • - 성격 : 학술지
  • - 간기 : 연3회
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 2384-1079
  • - 수록범위 : 1994–2021
  • - 수록 논문수 : 753