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P010 Ellagic acid protects human dermal papilla against UVA-induced oxidative stress

P010 Ellagic acid protects human dermal papilla against UVA-induced oxidative stress

( Hye In Cheon ) , ( Min Seok Hur ) , ( Byung Gon Choi ) , ( Song Hee Han ) , ( Min Jung Kim ) , ( Hae Jeong Youn ) , ( Soo Young Kim ) , ( Nam Kyung Roh ) , ( Yang Won Lee ) , ( Yong Beom Choe ) , ( Kyu Joong Ahn )

- 발행기관 : 대한피부과학회

- 발행년도 : 2016

- 간행물 : 프로그램북(구 초록집), 68권 2호

- 페이지 : pp.345-345 ( 총 1 페이지 )


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1,000
논문제목
초록(외국어)
Background: One of solar radiation components, ultraviolet A (UVA), has deeply penetrating capacity and generates reactive oxygen species (ROS) in the skin. These characteristics arouse oxidative stress in dermis, such as photoproducts, senescence, cell death, inflammation, and alterative gene expression. Objectives: This study aimed at investigating the antioxidant and anti-inflammatory effects of ellagic acid on UVA-irradiated human dermal papilla cells (HDPCs). Methods: The cell viability of HDPCs were analyzed using the water-soluble tetrazolium salt (WST-1) assay. 2,7-dichlorofluorescin diacetate (DCFH-DA) was used in evaluating intracellular ROS scavenging activity. All the mRNA expression levels were carried out via quantitative real-time polymerase chain reaction (qRT-PCR). Cellular senescence was evaluated using senescence-associated β -galactosidase (SA-β-gal) staining kit. Results: In irradiated HDPCs, ellagic acid showed protective effects on UVA-induced cytotoxicity. Further, ellagic acid represented ROS scavenging activity and regulating antioxidant gene expression, catalase transcriptional levels under UVA-irradiated condition. It also modulated tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) mRNA expresison levels and cellular senescence on UVA-stimulated HDPCs. Conclusion: These results demonstrate that ellagic acid protects UVA-induced oxidative stress in HDPCs.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 68권 2호
  • - 발행년도 : 2016
  • - 페이지 : pp.345-345 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2017-510-000582094
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2022
  • - 수록 논문수 : 25723