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P041 Epigallocatechin gallate protects against the effects of 5α-dihydrotestosterone by changes of microRNAexpression profil

P041 Epigallocatechin gallate protects against the effects of 5α-dihydrotestosterone by changes of microRNAexpression profil

( Hae Jeong Youn ) , ( Hye In Cheon ) , ( Min Seok Hur ) , ( Byung Gon Choi ) , ( Song Hee Han ) , ( Min Jung Kim ) , ( Soo Young Kim ) , ( Nam Kyung Roh ) , ( Yang Won Lee ) , ( Yong Beom Choe ) , ( Kyu Joong Ahn )

- 발행기관 : 대한피부과학회

- 발행년도 : 2016

- 간행물 : 프로그램북(구 초록집), 68권 2호

- 페이지 : pp.358-359 ( 총 2 페이지 )


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논문제목
초록(외국어)
Background: Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated cell death, cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence. Protective effects against DHT have not, however, been elucidated at the genome level. Objectives: We wanted to show that epigallocatechin gallate (EGCG), a major component of green tea, protects DHT-induced cell death by regulating the cellular miRNA expression profile. Methods: We used an miRNA microarray to identify miRNA expression levels in human dermal papilla cells DPCs). We investigated whether the miRNA expression influenced the protective effects of EGCG against DHT-induced cell death, growth arrest, intracellular ROS levels, and senescence. Results: EGCG protected against the effects of DHT by altering the miRNA expression profile in human DPCs. In addition, EGCG attenuated DHT-mediated cell death and growth arrest and decreased intracellular ROS levels and senescence. A bioinformatics analysis elucidated the relationship between the altered miRNA expression and EGCG-mediated protective effects against DHT. Conclusion: Overall, our results suggest that EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 68권 2호
  • - 발행년도 : 2016
  • - 페이지 : pp.358-359 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2017-510-000582403
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2022
  • - 수록 논문수 : 25723