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> 대한피부과학회 > 프로그램북(구 초록집) > 69권 2호

Anti-wrinkle effect of glycosaminoglycans through ERK and TGF-β signaling in human dermal fibroblasts

Anti-wrinkle effect of glycosaminoglycans through ERK and TGF-β signaling in human dermal fibroblasts

( Guk Jin Jeong ) , ( Jae Min Kim ) , ( Jungtae Na ) , ( Kapsok Li ) , ( Beom Joon Kim )

- 발행기관 : 대한피부과학회

- 발행년도 : 2017

- 간행물 : 프로그램북(구 초록집), 69권 2호

- 페이지 : pp.358-359 ( 총 2 페이지 )


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논문제목
초록(외국어)
Background: Glycosaminoglycans (GAGs) are known to play an important role in the anti-aging process of skin. However, the exact molecular mechanism underlying the anti-aging effect of GAGs is not fully understood. Objectives: This study was conducted to investigate the influence of GAGs on proliferation, collagen synthesis, and collagen synthesis-related signaling pathways in human dermal fibroblasts (HDFs). Methods: HDFs obtained by skin biopsy were treated with differently concentrated GAGs. Viability and proliferation was determined using an MTT assay. RT-qPCR and ELISA were used for quantitative determination of collagen synthesis. Enzyme and gene expression related with collagen turnover process were evaluated by Western blot and immunocytochemistry. Results: GAGs stimulated fibroblast proliferation and the synthesis of type I collagen. Furthermore, GAGs consistently reduced MMP-1 and increased TIMP-1 via inhibition of ERK signaling as well as activation of TGF-β/SMAD signaling in HDFs. Conclusion: Our findings indicate the application of GAGs as potential effective anti-aging agents to reduce wrinkles.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 69권 2호
  • - 발행년도 : 2017
  • - 페이지 : pp.358-359 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-004098640
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2021
  • - 수록 논문수 : 24140