Gamma-aminobutyrate (GABA) is an important precursor for synthesis of biodegradable polyamide 4 (PA4). Biorefinery for production of PA4 can be established by fermentative production of GABA from renewable resources using recombinant microorganisms. In this presentation, we report development of C. glutamicum strains expressing mutant glutamate decarboxylase. To develop recombinant strain capable of co-consumption of glucose and xylose, xylose utilization genes from E. coli was also introduced in recombinant C. glutamicum KCTC 1852. Detailed results will be presented.
** This work was supported by the Mid-career Researcher Program from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea (NRF-2016R1A2B4008707), a basic research grant from the KRIBB, and the Lignin Biorefinery from MSIT through the NRF of Korea (NRF- 2017M1A2A2087634).