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> 한국공업화학회 > 한국공업화학회 연구논문 초록집 > 2018권 0호

RE-ORGA to Alleviate DHT-induced Male Baldness in Human Dermal Papilla Cells

RE-ORGA to Alleviate DHT-induced Male Baldness in Human Dermal Papilla Cells

권보선 , 강명균 , 박대의 , 한형윤 , 심혜은 , 홍윤정 , 문지연 , 윤석주

- 발행기관 : 한국공업화학회

- 발행년도 : 2018

- 간행물 : 한국공업화학회 연구논문 초록집, 2018권 0호

- 페이지 : pp.315-315 ( 총 1 페이지 )


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논문제목
초록(외국어)
Testosterone and dihydrotestosterone(DHT) that are affect hair loss. 5α -reductases are converting testosterone into DHT. In hair loss processes, TGF-β1, DKK-1, DHT/DHT-AR(androgen receptor) complex are key factors. RE-ORGA was extracted from natural ingredient to alleviate hair loss with less adverse effects. This study showed that RE-ORGA can induce proliferation of dermal papilla and regulate molecular signaling pathway. Western blot analysis treated with RE-ORGA showed lowered expression of 5α-reductases. From RNA-Seq their expression was also examined to be decreased in transcriptional levels. Log-scaled fold changes of SRD5A1,3 and Bax were -0.518, -0.253, -0.758. Androgen receptor and TFGB1I1, co-activator for androgen receptor, were also down-regulated. On the other hand Ptk2b that is negative androgen receptor regulator showed over-expression. These results showed that RE-ORGA could regulates hair loss induced by testosterone and DHT.

논문정보
  • - 주제 : 공학분야 > 화학공학
  • - 발행기관 : 한국공업화학회
  • - 간행물 : 한국공업화학회 연구논문 초록집, 2018권 0호
  • - 발행년도 : 2018
  • - 페이지 : pp.315-315 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-003819167
저널정보
  • - 주제 : 공학분야 > 화학공학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1990–2022
  • - 수록 논문수 : 50686