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> 한국장기요양학회 > 한국장기요양학회 추계학술대회자료집 > 2018권 0호

Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction

Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction

( Dae Hyun Kim ) , ( A Kyoung Lee ) , ( Min Kyung Hyun ) , ( Sugyeong Ha ) , ( Eun Jin Bang ) , ( Sang Gyun Noh ) , ( Byeong Moon Kim ) , ( Hee Jin Jung ) , ( Hae Young Chung )

- 발행기관 : 한국장기요양학회

- 발행년도 : 2018

- 간행물 : 한국장기요양학회 추계학술대회자료집, 2018권 0호

- 페이지 : pp.190-190 ( 총 1 페이지 )


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논문제목
초록(외국어)
β-Hydroxybutyrate (HB) is a ketone body used as an energy source that has shown anti-inflammatory effects similar to calorie restriction (CR); however, its underlying mechanism remains unknown. Here, we examine the novel signaling mechanism of HB in aging-related inflammation. The FoxO has been proposed to promote resistance to oxidative stress and inhibits expression of pro-inflammatory genes through the PI3K/Akt pathway. Another pro-inflammatory transcription factor is NF-kB, which upregulates cytokine expressions. However, PGC-1α, an abundantly expressed co-factor in the kidney, was reported to interact with both FoxO1 and NF-kB although the definitive interactive mechanism has not yet been reported. In this study, we investigated whether renal aging-related inflammation is modulated by HB. We compared aged rats administered with HB to calorie restricted rats and examined the modulation of FoxO1 and the NF-kB pathway through interactions with PGC-1α. We found that in aged rats treated with HB, pro-inflammatory signaling changes were reversed and showed effects comparable to CR. As FoxO1 and its target genes catalase/MnSOD were upregulated by HB treatment and PGC-1α selectively interacted with FoxO1, not with NF-kB, and ameliorated the renal inflammatory response. These findings were further confirmed using FoxO1 overexpression and siRNA transfection in vitro. Our findings suggest that HB suppressed aging-related inflammation as a CR mimetic by enabling the co-activation and selective interaction between FoxO1 and PGC-1α. This study demonstrates the potential therapeutic role of HB as a CR mimetic, which ameliorates inflammation by a novel mechanism where FoxO1 outcompetes NF-kB by interacting with PGC-1α in aging kidneys.

논문정보
  • - 주제 : 사회과학분야 > 사회복지
  • - 발행기관 : 한국장기요양학회
  • - 간행물 : 한국장기요양학회 추계학술대회자료집, 2018권 0호
  • - 발행년도 : 2018
  • - 페이지 : pp.190-190 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2019-300-001426057
저널정보
  • - 주제 : 사회과학분야 > 사회복지
  • - 성격 : 학술지
  • - 간기 : 연간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 2013–2020
  • - 수록 논문수 : 112