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> 한국장기요양학회 > 한국장기요양학회 추계학술대회자료집 > 2018권 0호

Supplementation with elenocysteine extends lifespan and modulates age-related physiological alterations in C. elegans

Supplementation with elenocysteine extends lifespan and modulates age-related physiological alterations in C. elegans

( Bo-kyoung Kim ) , ( So-hyeon Kim ) , ( Jun-sung Kim ) , ( Sang-kyu Park )

- 발행기관 : 한국장기요양학회

- 발행년도 : 2018

- 간행물 : 한국장기요양학회 추계학술대회자료집, 2018권 0호

- 페이지 : pp.194-194 ( 총 1 페이지 )


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논문제목
초록(외국어)
Selenocysteine is a sulfur-containing amino acid and modulates cellular oxidative stress defense system. Selenocysteine show a preventive effect on cancer, neurodegenerative diseases, and cardiovascular disease. We examined the effects of well-known anti-oxidant amino acid derivative, selenocysteine, in response to environmental stressors and aging using C. elegans as a model system. Dietary supplementation with selenocysteine significantly increased resistance to oxidative stress. Survival after ultraviolet irradiation was also increased by supplementation with selenocysteine. Treatment with selenocysteine confers a longevity phenotype without accompanying reduced fertility, which is frequently observed in lifespan-extending interventions as a trade-off in C. elegans. Age-related decline in motility was significantly delayed by supplementation of selenocysteine. Lifespan assay with long-lived mutants revealed the effect of selenocysteine specifically overlapped with that of eat-2 mutation, a genetic model of dietary restriction. The mimicking of dietary restriction by selenocysteine required SKN-1. Selenocysteine delayed paralysis induced by amyloid beta, which is positively correlated with the incidence of Alzheimer’s disease. The effect of selenocysteine on amyloid beta-induced toxicity was dependent on nuclear localization of DAF-16. In addition, reduced survival caused by high-glucose-diet was recovered by selenocysteine. Selenocysteine reduced cellular level of reactive oxygen species, which is increased by high-glucose-diet. These findings suggest that dietary supplementation of selenocysteine can modulate response to stressors and mimics the effect of DR on lifespan and age-related pathophysiological alterations.

논문정보
  • - 주제 : 사회과학분야 > 사회복지
  • - 발행기관 : 한국장기요양학회
  • - 간행물 : 한국장기요양학회 추계학술대회자료집, 2018권 0호
  • - 발행년도 : 2018
  • - 페이지 : pp.194-194 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2019-300-001425909
저널정보
  • - 주제 : 사회과학분야 > 사회복지
  • - 성격 : 학술지
  • - 간기 : 연간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 2013–2021
  • - 수록 논문수 : 120