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> 대한화장품학회 > 대한화장품학회지(J. Soc. Cosmet. Scientists Korea) > 22권 2호

The Synthesis and Sfety of 3-Aminopropyl dihydrogen phosphate, a New Anti-aging Agent

The Synthesis and Sfety of 3-Aminopropyl dihydrogen phosphate, a New Anti-aging Agent

( Pyun Young Hoon ) , ( Ko Jae Sook ) , ( Cho Yoon Gi ) , ( Cheon Ji Min ) , ( Lee Bo Seaub )

- 발행기관 : 대한화장품학회

- 발행년도 : 1996

- 간행물 : 대한화장품학회지(J. Soc. Cosmet. Scientists Korea), 22권 2호

- 페이지 : pp.174-181 ( 총 8 페이지 )


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4,500
논문제목
초록(외국어)
The novel synthesis of 3-aminopropyl dihydrogen phosphate(3-APPA; 3-Aminopropane phosphoric acid), and its applicability to the skin as a cosmetic raw material in terms of its efficacy and toxicology were presented. The phosphorylation of 3-amino-1 -propanol was carried out via cyclization into 6-mem- bered 2,6-oxaza-phosphoryl ring in the presence of phosphorous oxychloride and an organic base. The subsequent ring-opening hydrolysis and crystallization afforded the highly purified product in 90% isoloated yield. The method is much superior to the previous literature phosphorylation methods, as the procedure is simple and high- yielding. To confirm the efficacy of 3-APPA, several activities related to anti-aging capacity were measured. In-vitro human fibroblast, linear and 3-dimensional collagen matrix culture revealed that 3-APPA stimulated the proliferation of fibroblasts, and enhanced the synthesis of collagen, which showed 3-APPA’s potency for skin wrinkle reduction. The toxicological aspect of 3-APPA was also extensively examined. In vivo toxicity tests such as acute oral toxicity, eye irritation, human patch, and the repeat insult human patch test proved 3-APPA to be a safe material. Thus 3-APPA can be used as an effective anti-aging agent for various cosmetic formulations.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한화장품학회
  • - 간행물 : 대한화장품학회지(J. Soc. Cosmet. Scientists Korea), 22권 2호
  • - 발행년도 : 1996
  • - 페이지 : pp.174-181 ( 총 8 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2019-500-001624517
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1226-2587
  • - 수록범위 : 1970–2021
  • - 수록 논문수 : 1138