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> 대한간학회 > 춘·추계 학술대회(The Liver Week) > 2020권 1호

Characteristics of Asymptomatic Patients with an “Elevated Serum Alpha-Fetoprotein Level” and Its Relationship with Hepatic Steatosis and Visceral Adiposity

Characteristics of Asymptomatic Patients with an “Elevated Serum Alpha-Fetoprotein Level” and Its Relationship with Hepatic Steatosis and Visceral Adiposity

( Sangmi Jang ) , ( Gwang Hyeon Choi ) , ( Sung-ho Hwang ) , ( Jaewon Park ) , ( Won Joon Choi ) , ( Woo Jin Jung ) , ( Eun Sun Jang ) , ( Jin-wook Kim ) , ( Sook-hyang Jeong )

- 발행기관 : 대한간학회

- 발행년도 : 2020

- 간행물 : 춘·추계 학술대회(The Liver Week), 2020권 1호

- 페이지 : pp.256-257 ( 총 2 페이지 )


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논문제목
초록(외국어)
Aims: Alpha-fetoprotein (AFP) is a well-known biomarker of liver cancer and liver injury. However, apparently healthy individuals having AFP elevation on heath check-ups were encountered in clinics. Their clinical features and cause of AFP elevation were not clear. Thus, we aim to investigate the clinical characteristics of the patients with an “elevated AFP level” (>7 ng/ mL cutoff), and its relation with body fat deposition in terms of hepatic steatosis and visceral adiposity. Methods: Patients having a diagnostic code of “elevated AFP level” (R772) were searched from 2009 to 2018 in a tertiary hospital. After excluding patients with any malignancies, liver cirrhosis, or viral hepatitis, 146 patients were included in the case group. As a control group, age and sex-matched 146 hepatic hemangioma (<3cm) patients were selected. Among the subgroup of case (n=49) and controls (n=49) who underwent liver CT, hepatic fat and visceral fat were measured using the pre-contrast CT image. Results: The case group showed a mean age of 48.7 years, male proportion of 64.4%, and a higher mean serum AFP level (12.76 ng/mL) than the control (2.85 ng/mL). The case group showed a higher prevalence of dyslipidemia (21.2 vs 3.4%, P<0.001) and hypertension (11.6 vs 4.8%, P=0.033), but a lower body mass index (BMI) (22.68 vs 23.85 kg/m2, P=0.003) than the control. Total-bilirubin level was higher in the case group (0.8 vs 0.5 mg/dL, P<0.001), but other laboratory results were similar to the control group. Hepatic fat measured by Hounsfield units of 8 regions of liver segments and visceral adiposity index in the subgroups of case and control were not different (59.40 vs 61.76, P=0.158 and 28.53 vs 27.32 ㎠/㎡, P=0.788, respectively). Conclusions: Asymptomatic patients with an elevated AFP level showed a higher prevalence of hypertension and dyslipidemia despite lower BMI than controls. Its relationship with abnormal fat metabolism warrants further study.

논문정보
  • - 주제 : 의약학분야 > 내과학
  • - 발행기관 : 대한간학회
  • - 간행물 : 춘·추계 학술대회(The Liver Week), 2020권 1호
  • - 발행년도 : 2020
  • - 페이지 : pp.256-257 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2021-500-001339196
저널정보
  • - 주제 : 의약학분야 > 내과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 2012–2021
  • - 수록 논문수 : 3540