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> 대한미용학회 > 대한미용학회지 > 16권 4호

왕벚나무 꽃 생물전환추출물이 섬유아세포의 콜라겐 합성 및 발현에 미치는 효과

The Effects of Prunus yedoensis Flowers Biorenovate Extract on Collagen Synthesis and Expression in Human Dermal Fibroblasts

박서연 ( Seo Yeon Park ) , 이승지 ( Seung Ji Lee )

- 발행기관 : 대한미용학회

- 발행년도 : 2020

- 간행물 : 대한미용학회지, 16권 4호

- 페이지 : pp.323-330 ( 총 8 페이지 )


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4,500
논문제목
초록(외국어)
Biorenovation modifies the structure of organic compounds, and thereby improving their biological properties. The current study aimed to examine the effects of Prunus yedoensis flowers (PYF) extract and the P. yedoensis flowers biorenovate (PYFB) extract on collagen synthesis and expression. Cytotoxicity on human dermal fibloblasts (HDF) was determined by cell viability assay kit (WST-8) assay. COL1A1, COL3A1, COL4A1 and elastin mRNA expression were confirmed by quantitative real time PCR. In addition, COL1A1, COL3A1 and elastin protein expression were confirmed by western blot. In vitro assays using the human dermal fibroblasts cells indicated that both PYF and PYFB extracts induced collagen synthesis. Quantitative real time PCR analysis showed that the treatment of these cells with the two extracts up-regulated the expression of COL1A1, COL3A1, COL4A1 and elastin factor genes, which are known to play a role in collagen synthesis. Notably, the effects of the PYFB extract were superior to that of the PYF extract. Therefore, our study suggests that PYFB extract could be developed as cosmetic ingredients with anti-aging effects that are better than PYF.

논문정보
  • - 주제 : 자연과학분야 > 가정
  • - 발행기관 : 대한미용학회
  • - 간행물 : 대한미용학회지, 16권 4호
  • - 발행년도 : 2020
  • - 페이지 : pp.323-330 ( 총 8 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2022-500-000287399
저널정보
  • - 주제 : 자연과학분야 > 가정
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2508-8009
  • - 수록범위 : 2005–2022
  • - 수록 논문수 : 720