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> 대한미용학회 > 대한미용학회지 > 16권 4호

해양 홍조류 에탄올 추출물의 RAW 264.7 세포와 HEKn 세포에서 항염증 효과

Anti-inflammatory Effects of Ethanolic Extracts from Marine Red Algae on RAW 264.7 and HEKn Cells

김세율 ( Se Yul Kim ) , 이숙영 ( Sook Young Lee ) , 김일철 ( Il Chul Kim )

- 발행기관 : 대한미용학회

- 발행년도 : 2020

- 간행물 : 대한미용학회지, 16권 4호

- 페이지 : pp.331-341 ( 총 11 페이지 )


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논문제목
초록(외국어)
The current study investigated the anti-inflammatory effects of ethanol extracts from marine red algae, namely Gracilaria verrucosa, Gracilaria vermiculophylla, Chondracanthus tenellus, and Gloiopeltis furcata in RAW 264.7 cells and HEKn cells. RT-PCR and Western blot analysis were used to confirm the mRNA expression and protein expression patterns of the major factors. Both the cells did not show cytotoxicity to the four red algae extracts. In the LPS-induced inflammatory cell model, iNOS production decreased with increasing concentration of the extracts. At 100 μg/mL concentrations of the extracts, G. verrucose showed the highest inhibitory activity (63.6%). COX-2 also showed an inhibitory effect of 85% or more in the four extracts. TNF-a and lL-1B showed the strongest inhibitory activities in the G. vermiculophylla (73.9%) and G. furcate (94.7%) extracts. In HEKn cells, the COX-2 production decreased significantly with increasing concentration. At 100 μg/mL extract concentration of iNOS and MMP-2, the most potent inhibitory effect was shown by the G. furcate (73.9%), and in both TNF-α and IL-1β, the G. verrucosa extract showed the strongest inhibitory effects at 47.8% and 41.7%, respectively. The ethanol extracts of the four domestic marine red algae are not cytotoxic, and contain effective substances with high anti-inflammatory properties, making them a functional natural material for cosmetics and pharmaceuticals. The value of their use is expected to be very high.

논문정보
  • - 주제 : 자연과학분야 > 가정
  • - 발행기관 : 대한미용학회
  • - 간행물 : 대한미용학회지, 16권 4호
  • - 발행년도 : 2020
  • - 페이지 : pp.331-341 ( 총 11 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2022-500-000287400
저널정보
  • - 주제 : 자연과학분야 > 가정
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2508-8009
  • - 수록범위 : 2005–2022
  • - 수록 논문수 : 720