This paper examines the ways in which healthcare professionals interact with patients`` family members, and/or colleagues. The data are from healthcare discourses at difficult times found in the manga series entitled Nurse AOI. As the first step, we selected several communication scenes for analysis in terms of politeness strategies. From these scenes, we extracted individual events that exhibit anyone of five main constraints/ maxims that follow Leech``s (2009) Grand Strategy of Politeness (GSP) framework- generosity/tact, approbation/modesty, obligation, opinion, and feeling. Then in-depth analysis was conducted using the following three perspectives: the contextual background of the communication, the relationship with patients`` family member and/or colleagues, and the degree of face-threatening acts. This last perspective was evaluated by Politeness Theory (Brown & Levinson, 1987), judging the imposition of face-threatening acts, social distance, and relative power. Each communication event was examined in terms of politeness strategies (Brown and Levinson, 1987; Yoshioka, 2007). At difficult times optimal politeness strategies are required while simultaneously providing urgent medical care for patients or victims. The findings of this study indicate both potential problems with healthcare communication at difficult times such as disasters and also suggest the ways in which the quality of communication may be enhanced.