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논문검색은 역시 페이퍼서치

보건정보통계학회지검색

Journal of Health Informatics and Statistics


  • - 주제 : 의약학분야 > 예방의학및보건학
  • - 성격 : 학술지
  • - 간기: 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2465-8014
  • - 간행물명 변경 사항 : 한국보건통계학회지(~2003) → 한국보건정보통계학회지(2004~)
논문제목
수록 범위 : 35권 1호 (2010)

CDH1 유전자 다형성 -160C>A와 대장결장암 발생에 관한 정량적 메타분석

조재승 ( Jae Seong Jo ) , 유미경 ( Mi Kyung Lyu ) , 박은정 ( Eun Jung Park ) , 설재웅 ( Jae Woong Sull ) , 지선하 ( Sun Ha Jee )
5,500
초록보기
Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene-160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data. Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer. Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1-160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p=0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p=0.001). Similarly, from 2 studies for CDH1-347G>A (rs5030625) in relation to colorectal cancer was 1.331 (1.029, 1.722; p=0.029). Conclusion: Our findings support that CDH1-160C>A is significantly associated with colorectal cancer risk. Further studies are needed.

임상시험 전자 자료 관리의 해외 규정 비교를 통한 전자자료 관리 기준 고찰

이현주 ( Hyun Ju Lee ) , 김영옥 ( Young Ok Kim ) , 조혜영 ( Hea Young Cho ) , 정면우 ( Myeon Woo Chung ) , 최인영 ( In Young Choi )
5,100
초록보기
Objectives: The use of electronic data management has grown to progressively replace paper-based clinical trials. Electronic data management must ensure the same data quality expected of paper clinical trials, by following Good Clinical Practice rules and relevant regulations. There was Korean Good Clinical Practice, however need more specific regulation to provide detail guideline. This study aims to compare international regulations for electronic clinical data management and explore the direction for Korean regulation for electronic clinical trials. Methods: Three international regulations, 21 CFR 11 of FDA, ANNEX 11 of EMEA, or ERES of Japan, are compared to find out requirements for quality, security and integrity of data. Requirements are analyzed through three perspectives; electronic records, electronic signatures and computerized systems. Results: Regulations commonly stated that electronic record should develop standard operation procedure, audit trail, features to copy records. In addition, time-stamped, record backup and accurate archival are proposed. Regulations for electronic signatures are precisely described in the FDA and Japan regulation. Finally, computerized system should be validated, and have security control, access control, and contingency plan. Conclusions: This study compared the representative regulations from three regulations and proposed recommended features for Korean regulation. This result can be provided to develop Korean regulation for electronic data management.

일개 대학 여대생에서 일차성 월경곤란증과의 관련된 생활습관, 스트레스, 월경력 및 식습관

이가현 ( Ga Hyeon Lee ) , 정휘수 ( Hwee Soo Jung ) , 이동욱 ( Dong Wook Lee ) , 박기흠 ( Ki Hm Park )
5,100
초록보기
Objective: Primary dysmenorrhea is a common gyecological problem in young women. We conducted this study to investigate the relations between life style, stress, menstrual history, dietary habits and primary dysmenorrhea. Method: 563 college women were participated in a cross-sectional study conducted between March 2 and 6 2009. The severity of dysmenorrhea in participants was assessed by the multidimensional scoring system reported by Andersch and Milson. State of stress, smoking and drinking, dietary habits as regularity of meal, breakfast and the consumption per week for soy, milk, egg, meat, fish, fruit and coffee were examined Result: 482 (85.6%) had any degree of dysmenorrhea and 183 (32.5%) had severe dysmenorrhea. Severe dysmenorrhea was related to high stress (OR=2.537, 95% confidence interval: 1.688-3.807), smoking (2.157, 1.048-4.437), earlier menarche than 13 years old (1.660, 1.138-2.420), and family history of dysmenorrhea (1.635, 1.161-2.304). No relations emerged between dietary habits, consumption of food and severity of dysmenorrhea, Conclusion: Primary dysmenorrhea is common in college women and severity of dysmenorrhea is related to stress, smoking, earlier menarche and family history of dysmenorrhea.

타액 중 코티닌 검출을 이용한 청소년 흡연 자가 보고의 타당도

설재웅 ( Jae Woong Sull ) , 지선하 ( Sun Ha Jee ) , 목예진 ( Ye Jin Mok ) , 최문영 ( Moon Young Choi ) , 바이사 , 오희철 ( Hee Choul Ohrr ) , ( Bayasgalan Gombojav )
5,100
초록보기
Objectives: This study was conducted to validate self-reported smoking using saliva cotinine among middle and high school students. Methods: A self report of smoking behavior was collected together with saliva sample for cotinine anlysis from 291 male and female students in middle and high school in 2003. Validity and agreement between self-reported smoking and saliva cotinine was analyzed with SAS 9.1 for different definitions of smoking status. Results: In validity test of male middle school students, sensitivity and specificity was 71.4 and 98.8. For male high school students, sensitivity and specificity was 100 and 80.6. In validity test of female high school students, sensitivity and specificity was 100 and 86.7. The concentrations of saliva cotinine were significantly different according to the smoking amount and the last time to smoke. Conclusions: The results showed the high validity of self-reported smoking among male and female high school students. However, due to the small sample size and limitation of the participants, it is cautious to generalize the results to all Korean adolescents.

또래모델링을 통한 일반아동의 이야기 다시 말하기 능력

이은정 ( Eun Jeong Lee ) , 최예린 ( Yae Lin Choi )
5,900
초록보기
This study selected 6 years old normal children(36 persons) who are increasingly improving story perfection as its subject, and performed the story recalling task to look into difference between the group who listened to the therapist`s story and the group who listened to peer friends` story. According to the results of the study, when children listened to the therapist or peer modeling friends` story, story-retelling recollection rate was not greatly affected. Similar structures were also recalled. Using these results, the peer modeling-centered program instead of the therapist-centered program needs to be constructed. In addition, considering the integrated child care center where the children with disability and the normal children live together, the peer modeling utilizing the participation of program development and provide opportunities for children with disabilities will be able to see. Finally, The follow-up study on story-retelling of the children of various age brackets, or with language developmental delay or specific language impairment is required by using the similar way of this study.

몽골이주노동자 미성년 자녀들의 건강상태와 장애요인에 관한 연구

박현주 ( Hyoun-Ju Park ) , 오희철 ( Hee Choul Ohrr ) , 이자경 ( Ja Kyoung Lee ) , 설동훈 ( Dong Hoon Seol )
5,400
초록보기
Objectives: The purpose of the study is to investigate the general health conditions among children of migrant workers in Korea and to make valid suggestions in implementing policies in related fields. Methods: A sample of the study consists of 89 migrant children and 321 Korean children of same age group living in the same region, and they were asked about subjects concerning social characteristics and health-related issues. Findings were analyzed by the SAS 8.0 system, and a chi-square test and a t-test were conducted to define any relational components among variables. Results: Male migrant children showed significantly higher score in the area of cognitive perception than the female counterpart, and a strong relation was noticed between sense of self-esteem and social support. Duration of migration was also found to be another positive element promoting positive self-awareness. Conclusions: The findings suggest some valid components to be considered, however, the study recommends a more systematic research in order to promote an awareness of their anthropological and social characteristics and to implement social programs and other health-related policies.
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