Objectives: The purpose of this study was to identify its influencing factors of depression in middle aged women. Methods: We analyzed cross-sectional data collected from 142 middle aged women by using self-reported questionnaire Korean version of Center for Epidemiologic Studies Depression Scale (CES-D), Menopause-specific Quality of life (MENQOL), Korean Perceived Stress Scale-10 (KPSS-10), Multiple dimensional Scale of Perceived Social Support (MSPSS), and Perceived health status. Data were analyzed stepwise multiple regression with SPSS 19.0. Results: The mean score for depression was 17.45. There were difference of depression scores in marital satisfaction (F=6.15, p=0.001) and quality of sleep (F=8.12, p≤0.001). There were difference of menopausal specific quality of life that were statistically significant in marital satisfaction (F=5.40, p=0.002) and quality of sleep (F=4.20, p=0.003). Depression was correlated with stress (r=0.69, p<0.001), social support (r=0.52, p<0.001), menopausal specific quality of life (r=0.52, p<0.001) and perceived health status (r=-0.44, p<0.001). The factors related to depression were stress (β=0.48, p<0.001), social support (β=-0.25, p<0.001), quality of life on menopause (β=0.18, p<0.001) which explained 56% of the variance reported in depression. Conclusions: The results indicate that these factors influencing depression should be considered when developing integrated intervention program to cope with depression in middle aged women.