Objectives: The purpose of this study was to identify prevalence and risk factors of needlesticks and other sharps injuries (NSIs) in education practicum among nursing students. Methods: Data were collected using self-administered questionnaires which included general and practical characteristics, in education practicum associated with NSIs. Data were conducted from April 29 to May 3, 2019 and analyzed using χ²-test and multiple logistic regression. Results: The incidence rate of NSIs was 17.0%. Multiple logistic regression analysis identified five predictors for NSIs which were statistically significant; year (Odds ratio, OR=3.88, 95% confidence interval, 95% CI=1.86-8.06), status carelessness (OR=2.32, 95% CI=1.22-4.40), wearing gloves (OR=2.86, 95% CI=1.39-5.86), finding an instrument in an inappropriate position (OR=2.77, 95% CI=1.46-5.25), and using time of instrument (OR=2.45, 95% CI= 1.19-5.06). Conclusions: Based on the findings of this study, we need to develop specific NSIs preventive education program for reducing the risk of NSIs of nursing students.