Objectives: Previous studies have mainly focused on the difficulties of families with cancer patients, so little is known about the factors involved in the positive adaptation of family caregivers. We explored how caring characteristics, information satisfaction, and family function affect the positive adaptation of caregivers. Methods: Cross-sectional survey within a university cancer hospital in South Korea was conducted. The collected data from 170 family caregiver with cancer patients were analyzed using descriptive statistics, t-tests, ANOVA, Pearson correlation, and hierarchical multiple regressions. Results: There were differences in scores for positive adaptation according to caregiver’s marital status, caring duration and patient’s treatment status, after diagnosis period. Positive adaptation was positively correlated with information satisfaction (r=0.36, p<0.001), decision-making engagement (r=0.25, p=0.001), and family function (r=0.37, p<0.001). In the final multivariate regression model, period after cancer diagnosis (β=1.77, p=0.033), information satisfaction (β=0.37, p=0.005), and family function (β=0.40, p<0.001) were significantly associated with more positive adaptation accounting for 25.9% for the variability. Conclusions: Period after cancer diagnosis, information satisfaction, family function was found to be a significant predictors of positive adaptation to family caregiver for cancer patients. Therefore, in order to promote positive adaptation of family caregivers for cancer patients, a systematic strategy for improving the function of these families will be needed. In addition, with quality information guaranteed, it is necessary to encourage participation in care based on positive adaptation of family caregivers.