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논문검색은 역시 페이퍼서치

Pediatric Infection and Vaccine검색

Pediatr Infect Vaccine


  • - 주제 : 의약학분야 > 소아과학
  • - 성격 : 학술지
  • - 간기: 연3회
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 2384-1079
  • - 간행물명 변경 사항 : 소아감염 → pediatric infection and vaccine
논문제목
수록 범위 : 3권 2호 (1996)

백신의 부작용

손영모
4,500
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초등학생의 베타용혈성 연쇄구균 보균자 검출에 있어서 인두부 중복배양(duplicate throat culture)의 유용성

차성호 ( Sung Ho Cha ) , 한미영 ( Mi-young Han ) , 최용묵 ( Yong-mook Choi ) , 길영철 ( Young Chul Kil ) , 서진태 ( Jin-tae Suh )
4,500
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소아의 항결핵제 사용 실태

김문희 ( Mun Hee Kim ) , 신영규 ( Young Kyoo Shin ) , 박상희 ( Sang Hee Park ) , 독고영창 ( Young Chang Tockgo )
4,500
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Tuberculosis in children is an important disease because of higher incidence and mortality, especially in developing and underdeveloped countries. The objectives of this study were to evaluate the cause of antituberculosis medication in children and to find out the basic data for proper drug regimen. We reviewed the medical records of 198 patients who had been treated with anti- tuberculosis drug from Jan. 1991 to Dec. 1993 in Anam Hospital of Korea University Medical Center. The results are as following; 1) Of 198 patients, 69 cases(34.8%) had treated due to BCG complications. They were all medicated with INH. The durations of medication were 3 months in 46 patients(66.7%), 4~6 months in 17 patients(5.8%), 7~9 months in 4 patients(5.8%), 10-12 months in 2 patients(2.9%). 2) Of 198 patients, 68 cases(34.3%) had treated due to chemoprophylaxis, 59 patients (29.8% of all cases) had histories of house hold contact. Of 68 cases, 51 patients (86.4%) were medicated with INH only, 8 patients (13.6%) were medicated with INH and RFP. 3) Other causes of antituberculosis medication were tuberculous lymphadenitis(14.1%), pulmonary tuberculosis(10.6%), meningitis, military tuberculosis(2.0%), and pleurisy(2.0%). Most common causes of antituberculosis medications in children were complication of BCG vaccination and chemoprophylaxis after household contact. So early detection of adult tuberculosis and development of convenient diagnostic methods and safe vaccine for childhood tuberculosis is necessary.

메티실린 내성 황색 포도상 구균에서 mecA, femA 유전자의 임상적 의의

박정은 ( Jung-eun Park ) , 김택선 ( Taek-sun Kim ) , 박수성 ( Su-sung Park ) , 김은령 ( Eun-ryoung Kim ) , 김일수 ( Il-su Kim ) , 안일영 ( Il-young Ann ) , 김영진 ( Young-jin Kim ) , 짐재종 ( Jae-jong Kim ) , 강성옥 ( Sung-ok Kang ) , 박한오 ( Han-ho Park )
4,500
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Purpose : In the treatment of MRSA infection, rapid detection of MRSA is extremely important. The mecA gene codes the new drug resistant polypeptides called PBP2’ which mediates the clinically relevant resistance to all beta-lactam antibiotics. The identical mecA gene has been found in coagulase-negative staphylococcus with the methicillin-resistant phenotype. On the other hand, the femA gene was absent from coagulase negative staphylococcus strains with the methicillin resistant phenotype. This study is aimed at early detection and definite diagnosis of MRSA. Methods : A total of 24 MRSA strains were studied. All strains were tested for antimicrobial susceptibility and purified DNA. We amplified both mecA and femA genes by PCR in 24 strains. Results : In MRSA all the 16 strains (100%) carried femA gene and 11 strains (68.7%) carried mecA gene. In contrast, in methicillin sensitive staphylococcus all the 8 strains (100%) carried femA and only 3 strains (37.5%) were detected mecA. Conclusions : As results, there are difference in the phenotype and genotype of methi-cillin resistance by PCR of mecA and femA. Such disparities between methicillin resistance and the presence of mecA gene suggest the presence of control gene of the mecA.

Coxiella burnetii감염과 가와사끼병과의 관련성에 관한 연구

김종욱 ( Jong Wook Kim ) , 이해용 ( Hae Yong Lee ) , 이원영 ( Won Young Lee )
4,500
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Purpose : Coxiella burnetii is a well-know causative agent of granuolmatous inflame-mation and an inducer of morphological change and transformation of human B lymphocyte in vitro. Coxiella burnetii manifests with several clinical symptoms depending upon the organs that are involved. We therefore undertook to clarify the association of Kawasaki disease and Coxiella burnetii. Subjects and Methods : The patient’s sera were tested for antibodies specific for Coxiella burnetii, using indirect fluorescent antibody technique(IFA). We compared Coxiella burnetii infection with 3 groups of patients, group 1 (Kawasaki disease), group 2 (other febrile disease) and group 3 (control group). Results : 1) In children with Kawasaki disease (group 1), 93% of the patient tested positive for Coxiella burnetii. 2) In group 2 children, 20% of the patient tested positive for Coxiella burnetii. 3) In group 3 children, 10% of the patient tested positive for Coxiella burnetii 4) There were significant higher positive rate for Coxiella burnetii in Kawasaki disease than group 2 and group 3 (p<0.05). Conclusions : We concluded that our cases of Kawasaki disease were associated with Coxiella burnetii infection. Further studies will be needed to understand the precise role of Coxiella infection in Kawasaki disease.

1996년 초여름에 유행한 Adenovirus폐렴의 검토

김창근 ( Chang Keun Kim ) , 정철영 ( Churl Young Chung ) , 김정숙 ( Jung Suk Kim ) , 이환종 ( Hoan Jong Lee )
4,500
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아데노바이러스에 의한 소아 하기도 감염에 대한 임상적 고찰

손진아 ( Jin-a Son ) , 이상일 ( Sang-il Lee ) , 이남용 ( Nam-young Lee ) , 김정희 ( Jung-hee Kim )
4,500
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Purpose : Adenoviruses(Ad) have been shown to play an important role in the etiology of severely acute respiratory diseases, particulary in infants and young children, and the occurrence of fatal outcome and chronic pulmonary sequelae in association with adenoviral infection has been a cause of great interest and concern. This report presents the resul of a retrospective analysis on 30 cases of lower respiratory infection from which adenovirus was isolated. Patients & Methods : The 30 patients in this study represent all detected cases of adenovial infection out of 240 children who were admitted to Sang Sung Medical Center between February to June 1996 showing signs and symptoms of lower respiratory tract infection. The diagnosis of adenovirus infection was based on microscopic visualization of typical cytopathic effect in HEp-2 tissue culture and used monoclonal Ab with naso-pharyngeal aspiration. Results : The male/female ratio was 2:1 and the majority of age range was below 36months. Clinical diagnoses in all 30 patients were pneumonia(n=21), bronchitis and Bronchiolitis(n=5) and ARDS(n=4). We recieved the most of patients in the month of May. The chief complaints were fever(93.3%) and cough(80%) and extrapulmonary symptoms were diarrhea(n=5), seizure(n=4), abdominal pain(n=1). The mean duration of fever was 11.95±6.54days. Physical examination on admission were crackles(73.3%), coarse breathing sounds(60%), hepatosplenomegaly(33.3%), decreased brething sounds(30%). In WBC counts, 8cases were below 4000/mm3 and 14 cases were above 10,000/mm3. In platelets counts, 4cases were below 150,000/mm3 and 10 cases were above 450,000/mm3. 21 cases were above 1 in CRP. GOT and GPT were abnormal in some cases. Chest X-ray revealed diffuse pulmonary infiltration(n=15), pleural effusion(n=6), consolidation(n=4) and hyper-aeration(n=3). Seven patients were treated at the peditric intensive care unit with respiratory support and high dose of gammaglobulin. However, one patients died even through he was treated with NO ventilation and high frequency ventilation. Conclusion : Those with adenoviral pneumonia and respiratory infection having long fever duration and symptoms like bacterial pneumonia must be carefully differentiated in order to provide proper treatement and preventive measures due to possible fatal outcome.

무균성 수막염 환자의 뇌척수액 채취 시기와 장바이러스 RNA 검출과의 관계

이규만 ( Kys Man Lee ) , 박순영 ( Soon Young Park ) , 강희정 ( Hee Jung Kang ) , 이은희 ( Eun Hee Lee )
4,500
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무균성 뇌막염에서 증상발현부터 진단까지 걸린 시간에 따른 시기별 유병기간의 검토

김탁수 ( Tag Soo Kim ) , 허지연 ( Ji Yeon Hur ) , 박영희 ( Young Hee Park ) , 정민구 ( Min Goo Jung ) , 김성원 ( Sung Won Kim )
4,500
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소아의 연령증가에 따른 볼거리 및 풍진 항체

전혜원 ( Heaewon Cheon ) , 신영규 ( Kangwoo Lee ) , 이강우 ( Youngkyoo Lee ) , 정지태 ( Jitae Chung ) , 독고영창 ( Youngchang Tockgo )
4,500
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Purpose : This study was intended to measure seropositivities and the levels of mumps-and rubella-specific IgG of MMR vaccines over 17 months of age in Korea. Materials and Methods : From June 1994 to April 1995 we obtained sera from visitors of well baby clinic and patients in Korea University Hospital, who were MMR vaccinees over 17 months of age and had no evidence of immunodeficiency. These 275 study population include 145 males and 130 females. Mumps- and rubella-specific IgG antibody levels were measured by ELISA. Cut-off values for seropositivity were 20 GU(Gamma Unit) in mumps and 0.17 in rubella. Results : 1) As age increased, seropositivities of mumps-specific IgG increased significantly, being 69.0% in 1.5~2 year, 75.0% in 3~4 year, 76.0% in 5~6 year, 90.0% in 7 year, 100% in 8 year, 96.9% in 9 year, 97.4% in 10 year, 97.4% in 11 year, and 96.6% in 12 year of age (p<0.001). 2) As age increased, the levels of mumps-specific IgG antibody(mean±standard deviation, GU) increased significantly, being 64.9±66.5 in 1.5-2 year, 117.7±126.4 in 3~4 year, 152.3±147.1 in 5~6 year, 194.3±168.2 in 7 year, 258.1±190.6 in 8 year, 193.1±130.1 in 9 year, 225.7±119.6 in 10 year, 220.7±114.3 in 11 year, and 222.3±127.1 in 12 year of age(p<0.001). There was positive correlation between age and mumps-specific antibody level (r=0.3282, p<0.001). 3) As age increased, seropositivities of rubella-specific IgG decreased significantly, being 72.4% in 1.5~2 year, 75% in 3~4 year, 72% in 5~6 year, 60% in 7 year, 44.4% in 8 year, 40.6% in 9 year, 28.2% in 10 year, 23.1% in 11 year, and 17.2% in 12 year of age(p<0.001). 4) As age increased, rubella-specific IgG decreased significantly, being 0.462±0.356 in 1.5~2year, 0.438±0.306 in 3~4 year, 0.287±0.179 in 5~6 year, 0.204±0.139 in 7 year, 0.189±0.153 in 8 year, 0.124±0.121 in 9 year, 0.093±0.114 in 10 year, 0.104±0.135 in 11 year, and 0.080±0.001 in 12 year of age(p<0.001). There was negative correlation between age and rubella-specific IgG titer (r=-0.551, p<0.001). Conclusions : Eventhough seropositivities and the level of mumps-specific IgG increased as age increased, they are not enough to prevent mumps infection in 1.5 to 6 years of age. Seropositivities and the level of rubella-specific IgG decreased as age increased. Appropriate change in vaccine schedule may be needed to decrease the risks of mumps and rubella infection.
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