The accumulation of intra-abdominal visceral fat is highly correlated with the metabolic abnormalities that contribute to increased risk of diabetes mellitus and cardiovascular disease. This study aimed to compare the general adiposity index (BMI) with abdominal obesity indices (waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR)) in order to examine the best predictor of cardiometabolic risk factors among Korean adults. We conducted a cross-sectional study where total and abdominal fatness were determined by anthropometric indices (BMI, WHR, WHTR, and WC). Pearson`s correlations was calculated between indices of obesity (BMI, WC, WHR and WHtR) and blood pressure (SBP, DBP), blood glucose (BG), triglyceride (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and total cholesterol (TC):HDL-C. In this cross-sectional study, 433 men and 362 women who participated in a health examination program were included. In both men and women, all four obesity indices significantly correlated with the cardio-metabolic risk factors. Correlation coefficients (r) between WHtR and cardio-metabolic risk factors were the strongest among the obesity indices, followed by WC and WHR. WHtR had the highest correlation coefficients for SBP, HDLC, LDLC, and TC/HDLC in both men and women. WHR had the highest correlation coefficients for TG and TC in men. Partial correlation coefficients, controlling for age, also indicated that the WHtR have the greatest association with almost of the health risk factors examined, specifically in male (p<.001). In conclusion, BMI tended to be the weakest index for identifying cardio-metabolic risk factors in both sexes. WHtR exhibited the best predictive index for cardio-metabolic risk, particular in men.